The tourist, who is holidaying in South Africa, presented with symptoms including a rash, muscle ache and fatigue.
His infection was confirmed as monkeypox by South Africa's National Institute for Communicable Diseases.
"Three contacts have already been identified and none of them have developed signs thus far," Limpopo health official Phophi Ramathuba said in a statement.
Earlier South Africa reported two monkeypox cases not linked to travel.
Monkeypox is a viral disease that causes flu-like symptoms and skin lesions. It is endemic in parts of Africa, but not South Africa.
More than 50 countries where monkeypox is not endemic have reported outbreaks of the viral disease as confirmed cases exceed 7,600.
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