Numerous studies have linked prolonged exposure to both endogenous (occurs naturally within the body) and exogenous (externally administered) oestrogen to breast cancer. In fact, research has consistently found that women who use Hormone Replacement Therapies (HRTs), typically prescribed to offset menopause symptoms, for five years or more increase their risk of breast cancer by approximately 35%.
Dr Gys du Plessis, advisor for DNAlysis Biotechnology, practicing in integrative and functional medicine and medical director for Nimue Bioscience, explains that sex steroids, such as oestrogen, have a variable metabolism that is strongly influenced by your DNA and other environmental factors.
"The 0.1% difference in every individual's genes creates a variance in biological processes, including oestrogen metabolism. The result is a genetic predisposition to certain diseases such as breast cancer, diabetes, cardiovascular disease and high cholesterol to name a few examples. Women who are genetically unable to efficiently metabolise and eliminate excess oestrogen face a significantly higher risk of developing breast cancer, particularly when taking additional hormones such as oral contraceptives or HRTs," says Du Plessis.
Thankfully, recent advancements in the Human Genome Project has led to the development of targeted DNA testing which provides invaluable insights into our genetic strengths and weaknesses.
Earlier this year, DNAlysis Biotechnology launched South Africa's first oestrogen metabolism genetic test, which identifies eight genes and 12 gene variations associated with oestrogen metabolism and detoxification in women.
"The test provides medical practitioners with a scientific tool to asses a patient's breast cancer risk and manage it accordingly. The information, coupled with other considerations unique to the individual means that doctors are far better informed prior to prescribing HRTs. Similarly, women making these lifestyle decisions are now also better informed of their risk," says Du Plessis.
The test is only available via healthcare practitioners who have completed the necessary training to interpret the findings and offer an informed diagnosis. A training programme is available via DNAlysis Biotechnology.
"Genetics is playing an increasingly important role in the diagnosis and holistic treatment of disease, and will change how we support health, diagnose and treat human disease and develop interventions. We hope that, within the next five years, the oestrogen metabolism test will be available to all women in South Africa," Du Plessis concludes.
For more information on DNAlysis Biotechnology, its various products as well as its healthcare practitioner training programme, call +27 (0)11 268 0268 or visit www.dnalysis.co.za, facebook.com/dnalysis or twitter.com/dnalysis.
