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| Strategise | Cape Town | Strategic Marketing Planning | |
| Streamlab | Cape Town | Live Broadcast and Stream | |
| Streamline Agencies | Cape Town | Accredited supplier of clothing and gifts | |
| Streetwize CT Casting Directors | Cape Town | Casting Director | |
| Strip Curtain Solutions | Strip curtains, Duralite doors, air curtains | ||
| Stronghold Publishing | Cape Town | Typesetting and layout | |
| Structural Mezzanine Floors | Cape Town | Structural Mezzanine Floors, manufacture & install | |
| Stuart Thompson Architects | Starc | Cape Town | Architectural Service | |
| Student News Africa | Cape Town | SA student media portal and community | |
| Studio 29 | Cape Town | Recruitment | |
| Studio Bo | Cape Town | Animation, illustration, motion graphics | |
| Studio Dolby | Stellenbosch | Graphic Design | |
| Studio Franco | Cape Town | Freelance all graphic design services | |
| Studio Franco Design | South Africa. | Design and Marketing | |
| Studio Haddock | Paarl | online media | |
| Studio X Solutions | Cape Town | Colour Quality Solutions, Marine Lubricants | |
| Studio Zafari | Cape Town | FILMING | GRAPHIC DESIGN | ANIMATION | EDITING | |
| STUMBELBLOC | Cape Town | plastic brick manufacturers | |
| Sublime Medical Supplies | Cape Town | Drug Tests/Related Consumables. | |
| Sublime Skin & Body | Cape Town | Facials, Body Treatments | |
| Success International | Cape Town | Display frames and systems/ framing | |
| SugarBird Creative Design | Logo's, weddings, kids parties, adverts, labels | ||
| SUKAVANA unleash your mind * embody your wisdom | Cape Town | Leadership Coaching | Personal Development | |
| Sumi Creative | Co | Artist, Designer, Furniture | ||
| Super Elite | cape Town | SA's specialists in high tech products. | |
| Super Shuttles Travel & Tours | Cape Town | Airport,Shuttle Transfers and Tours | |
| Superb Digital | Website design/development | ||
| Superiate | cape town | Brand Strategy, Campaign Management, Youth Focus | |
| Supernice | Web and mobile apps | ||
| Superseed Studio | Cape Town | Digital marketing, Brand Design, Web Development | |
| Surge Digital | Cape Town | Digital Marketing | |
| Surgical Bliss | Cape Town | Medical Tourism | |
| Surgo | Cape Town | Surgo manages a wide range of Outsourcing function | |
| Surgo (Pty) Ltd. | Cape Town | Outsourcing | |
| Surika Belly Dance Entertainment | Cape Town | Professional Solo & Troup Performances | |
| Sustainable.co.za | Cape Town | Online Eco Store | |
| Suzuki Cape Town | Cape Town | Suzuki Cape Town | |
| Suzuki Helderberg | Cape Town | Car Dealers | |
| SW Carpentry & Contractors | Strand | Bespoke design, carpentry, finishes, construction | |
| SwanCircle | Cape Town | User Experience Design | |
| Swarm Loyalty | Cape Town | PoSIntegrated Mobile Loyalty/Consumer Engagement | |
| Swey Design | Stellenbosch | Communications, PR, Graphic Design, Publishing | |
| Swift Chauffeur and Transfer Services | Cape Town | Airport transfers, tours, chauffeur, travel, taxi | |
| Swift Displays | Cape Town | Large Format Printers | |
| Swimlab Swim School | Cape Town | Swim Lessons/Water Safety/Coaching/Aquatics | |
| Swimming Pool Pros Cape Town | Cape Town | Swimming Pool Pros | |
| Swimming Pool Pros Somerset West | Somerset West to Strand | Swimming Pool Pros | |
| Symbiosys IT | Cape Town | SOLUTIONS OVERVIEW BUSINESS CONSULTING BUSINESS SO | |
| Symbiote Web Development | Cape Town | Website Design | |
| Synchron Markings | Cape Town | Foil and Media Supplier | |
| Syntagm Research | Zendesk Integration and management | ||
| SyntechSA | Cape Town | IT hardware | |
| Table View Glass and Aluminium | Cape Town | Glass and Aluminium Supplier | |
| TAG 8 | Cape Town | Building Brands with Purpose | |
| TAG COLLECTIVE | Cape Town / | MARKETING COLLECTIVE. | |
| Tagfire UX | Cape Town | User Experience | |
| Take My Word | Mowbray | Pitch and Persuasive Presentation Training | |
| Talent Network | Cape Town | Recruitment, HR Consulting and Coaching | |
| Talk Functions | Cape Town | Function & Wedding Co-ordination | |
| Talk Functions (Pty) Ltd | Cape Town | Event management | |
| Talking Radio | George | Facilitation and Training | |
| TallOrder POS | Paarl | Cloud Point od Sale | |
| Tania V Consulting | Cape Town | HR, Industrial Relations,Recruitment | |
| Tanja Meyburgh, Counseling Psychologist | Cape Town | Systems Constellations | |
| Tap and Die | Cape Town | Broken bolt removal mobile thread repairs engineer | |
| Tar-A-Way SA | Cape Town | Tar and Civils, Road Maintenance | |
| Tarangaan Publishing Solutions | Cape Town | Publishing made easy | |
| TAS Business Solutions | Cape Town | Business Development - Learnerships - Skills Devel | |
| Task Me | Cape Town | Online Marketing and Virtual Business Assistant | |
| Tasyam Govender Town Planner | Cape Town | Spatial Planning and Land Use Management | |
| Tata International Cape Town | Matroosfontein | Daewoo & Tata Truck Dealership, Workshop and Parts | |
| Taurus Business Holdings | Cape Town | Security Services | |
| TaxTim | Cape Town | Tax return service | |
| TCB Media | Cape Town | Magazine and Digital Publishers, Advertising | |
| TCG Cape | Cape Town | IT Support and Managed Services | |
| Tcgcape | Cape Town | IT Support and computer servies | |
| TEAM Precision | Cape Town | Engineering | |
| Teamworks | Cape Town | Marketing Strategy Development and Implementation | |
| Tech Genius | Brackenfell | Tech Genius | |
| Techbuying | Cape Town | Supplying Consumer electronics Products. | |
| Techmat Plumbing | Betty's Bay | Plumbing services & Renovations | |
| Techsbox | Creative Content, Design, and Web Development | ||
| Techsys Digital | Cape Town | Digital marketing/advertising | |
| Techtron Business IT Services | Cape Town | Cyber Security, MSP, Firewall, Microsoft, Manage I | |
| Tekano | Cape Town | Fellowship | |
| Telazac | Sound, Lighting, Stage, Audiovisual, Tent Lighting | ||
| Tempehsa (Pty) Ltd | Cape Town | Tempeh Producer | |
| Tenacious | Cape Town | Branding • Design • Digital • Strategy | |
| Tenacity Works | Cape Town | We design brands, websites and digital products. | |
| Tenga Dezign CC | Oudtshoorn | Building Maintenance & Repairs,Painting,Steelworks | |
| Terrabusiness Agency | Cape Town | Multi Media Marketing, IT Consulting, WebDesign | |
| Terri Love Designs | Cape Town | Graphic & Web Design | |
| Tessa Fenton-Wells | Cape Town | Ad Sales | |
| Tessa FentonWells | Cape Town | Media Marketing and Sales | |
| TextBOX Conceptual | Cape Town | Copy writing and public relations | |
| That Little Shop | Cape Town | Homeware, Decor & Gifts | |
| The Acupuncture Centre | Cape Town | Acupuncture |
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