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| Social Enterprises Management Accountants | Johannesburg | Small Business Consulting and Accounting | |
| Stanley Robert Investments (Pty) Ltd | Johannesburg | Property Rentals | |
| Sympl Technology Solutions | Midrand | Mobile Apps, Software Development, Data Management | |
| Small Business Runway | Boksburg | Exhibitions and Event Management | |
| Thumbtribe | Ballito | Measurable engagement in store & online | |
| XL OCEANAIR TRAVEL | Johannesburg | Travel & Tourism | |
| U The Difference Group Entertainment | Germiston | Entertainment | |
| THE EARTH WORX | Johannesburg | Civils, open-cast, mining,construction,Demolitions | |
| SkyBrite Media cc | Cape Town | Sandz Group is a PR&Marketing CO in Cape Town(SA) | |
| Sheba Marketing & Promotions | Pretoria | Event Management | |
| Sheer Glass | Sandton | Glass and aluminium supplier | |
| Shimba Marketing Distribution and Promotons | Randburg | Distribution and promotions | |
| Waydz Candle Creations | Cape Town | Events decor, Thank you gift, favours | |
| SHO MAN Media House | Boksburg | Event Filming | |
| Shopfitting Concepts | Pretoria | Manufacturing | |
| ShopFront | Gauteng | SHOP DISPLAYS & EQUIPMENT, WE SELL SLAT BOARDS, | |
| Sichri - Eyewear Straps | Port Elizabeth | accessories | |
| Sichri Eyewear Straps | Port Elizabeth | Manufacturing eyewear straps | |
| Signa Group | Randburg | B-BBEE Consulting, Services, Solutions | |
| Signa Higher Education | Randburg | Bursary Management | |
| Signa Trust | Randburg | Female Student Support | |
| Signature Brand Clothing | Bloemfontein | Manufacture local designs | |
| Signature Productions | Cape Town | Events Management | |
| SignForce | Johannesburg | Signage manufacture and installation in Africa | |
| Sign Image | Pretoria | Signage Company Gauteng | |
| Silverworx Staffing Solutions | Umhlanga | catering, events, mobile bartenders, waiters | |
| SIMcontrol | Cape Town | Business SIM Management Platform | |
| Simplify 360 | Bangalore | simplify 360 is the best review managment software | |
| Siqobile Events Management and Catering | Johannesburg | Event planning and management, catering | |
| Sirticket | Johannesburg | Ticketing & Access Management | |
| Sivatho Chuma Wealth Managers | Mthatha | Business Advisory | |
| Siyakula Events | Centurion | Conceptualisting and management of events | |
| Siyasebenza Manufacturing | Hammarsdale | Siyasebenza Manufacturing | |
| Siyembili Consulting & Business Services | Research & Business Consulting | ||
| Skilltech Labour | Roodepoort | IT Placements and Labour Staffing | |
| Smart Labour Consultants | Springs | Labour law compliance consultancy | |
| Smart Social | Pretoria | Social Media Marketing | |
| Soapbox Communications | Cape Town | Media relations and communications consultancy | |
| Social Incubator | Fourways | social media marketing | |
| Social Media Shop | Cape Town | Social Media Marketing and Advertising | |
| Socio-Dex | Cape Town | Research & Advisory firm | |
| Soit Business Solutions | Randburg | Computer Company | |
| Solid Systems | Cape Town | Microsoft Specialists | |
| Solutions Connect Training and Consulting Africa | Bettys Bay | Innovation and Service Consulting and Training | |
| Solutions Group Events | Bryanston | Conference & Event Management, Incentive Travel | |
| Sondlo & Knopp Advertising | East London | Advertising (TTL) | |
| Sonnenberg & Associates Property & Legal Advice | Cape Town | Property and legal advice | |
| So Shine Events Management | Pretoria | Conferencing, Travel | |
| Soul Good | Port Elizabeth | Events, Sport and Activation Management | |
| Soulshifters Entertainment | Brits | Media Production | |
| SoulWorx Events | Johannesburg | Content provider | |
| Source Content Marketing Agency | Content Marketing | ||
| Southern Kitchens | Durban | Kitchen Cupboard Installation | |
| Southern Spoor | Fourways | Marketing of hotels and lodges | |
| Southern Staying South Africa | Struis Bay | Vacation Accommodation Service Providers | |
| Sowertech | Germiston | Project Management | |
| Soweto Voyage | Soweto | Tours Travel | |
| Spartan Business Solutions | Johannesburg | IT and business services | |
| Spearhead Schemes Management | Kempton Park | Administration & legal support - community schemes | |
| SP Investment Holdings | Johannesburg | strategy; consulting; training and development | |
| Spiral Productions | Johannesburg | Creative brand live theatrical experience agency. | |
| Spitfire | Johannesburg | Branding | |
| Spy Agency | Johannesburg | Counter-Surveillance, GPS Tracking | |
| SR Communications | Durban | Business Consulting, Business Plans and Funding Sp | |
| Sree Manasa Psychiatric Nursing Home | hospital | ||
| Staff Training | Cape Town | Training | |
| Stage Audio Works | Johannesburg | Audio, Video, Lighting, Rigging & Structures | |
| Stainless Design | Port Elizabeth | Stainless Steel Manufacturing and supply | |
| Starlite Media | Port Elizabeth | Event management and Live Entertainment | |
| Steam And Valves Specialists | Johannesburg | Steam And Valve Specialists | |
| Sterling Hospitality | Cape Town | Hotel Resort Management/Development | |
| Stoi Business Consultants | Sandton | Enterprise dev, business consulting & project | |
| Stokdirect Virtual Wholesale | FMCG Wholesale & Distribution | ||
| Stoneshield | Johannesburg | Manufacturer of natural floor sealants | |
| Stormtech | Cape Town | Business software development and web applications | |
| Storybook - Brand Communication Consultancy | Durbanville | We are reputation managers and brand storytellers | |
| Stractiv8 | Johannesburg | Communications & Digital Engagement | |
| Straight Up Bar Solutions | Johannesburg | Outsourced Bar Solution / Mobile Bars | |
| Structural Mezzanine Floors | Cape Town | Structural Mezzanine Floors, manufacture & install | |
| Studio X Solutions | Cape Town | Colour Quality Solutions, Marine Lubricants | |
| STUMBELBLOC | Cape Town | plastic brick manufacturers | |
| Stunning Creations | Pretoria | Shopfitting | |
| Sublime Skin & Body | Cape Town | Facials, Body Treatments | |
| Success Mantra | education | ||
| SUKAVANA unleash your mind * embody your wisdom | Cape Town | Leadership Coaching | Personal Development | |
| Superior Virtual Assistance | Pretoria | Virtual administrative & formatting assistance | |
| Supreme Shopfitters | Johannesburg | Manufacture/Installers of Shopfittings/Furn. | |
| Suzan Ntebo and Associates(PTY)LTD | Johannesburg | Communications and Events Management company. | |
| SV Capital | Johannesburg | Investment | |
| Svn Events Management and Marketing | Johannesburg | Events planning and marketing | |
| Sweatshirt Manufacturers | WE OFFER BEST QUALITY SWEATSHIRT ALL OVER THE WORL | ||
| Swell Communications | Pretoria | Public Relations | |
| Symbiosys IT | Cape Town | SOLUTIONS OVERVIEW BUSINESS CONSULTING BUSINESS SO | |
| SynerG Events - Conferencing & Corporate Events | Sandton | Conferencing & Corporate Milestone Events | |
| Synergistic Outcomes | Durban | Strategic Planning, Skills training, Job Fit | |
| Synertech | Johannesburg | Radio Frequency Identification | |
| Syntegrate | Johannesburg | Publicity & Content Development | |
| Synthesise | Roodepoort | Content and Sponsorship Marketing and Platforms | |
| Syrupe Media | Johannesburg | Influencer Marketing & Personality Management |
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