Research in the news: Yale researchers find human-specific gene that turns back cellular clock

A colony of embryonic-like cells form after activation of a gene variant only found in humans, essentially reprogramming mature cells.

The discovery of a human-specific gene involved in such a fundamental process as the creation of a pluripotent cell, one that can become a variety of tissue types, surprised Yale researchers. The gene called CCNE1 is normally involved in cell cycling, but the variant CCNE1 does not appear to play that role and instead appears critical for reprogramming. It is also unclear why the gene is found only in in primate cells.

The Yale team, led by geneticist In-Hyun Park, is studying how mature cells can be reprogrammed back to their embryonic state. The goal of the research is to better understand the processes of cell fate change and one day develop customized cell therapies for individual patients.

The Yale team used a new form of transciptome analysis that allowed them to more fully explore impact of all types of RNA on cell reprogramming. The work will be published in 6 June 2015 issue of Stem Cell Reports.

Source: Yale University