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| Skyfield Marketing | Sandton | Event Rental Products | |
| Skysite Rope Access | Johannesburg | Rope access | |
| Skytrax Accounting and Payroll Services | Johannesburg | Accounting and Payroll | |
| Sl Productions | Roodepoort | High end photography and video production | |
| SL Studios | Pretoria | Graphic Design | |
| Slalom Marketing Consulting | Johannesburg | Development of business marketing strategies | |
| SLAM PRODUCTION | Johannesburg | Music Publishing | |
| Sleeping Giant Technology | Randburg | Voip Landline | |
| Slick Click Virtual Assistant | Virtual Assistantance | ||
| Slif | Johannesburg | Artist Development | |
| Small Business Runway | Boksburg | Exhibitions and Event Management | |
| Smart Cart trading as Smart Media | Johannesburg | In-Store Advertising | |
| Smart Events | Roodepoort | Event Management Consultancy | |
| Smart Labour Consultants | Springs | Labour law compliance consultancy | |
| Smart Money - Financial Experts | Johannesburg | Financial wellness | |
| Smart Social | Pretoria | Social Media Marketing | |
| SmartDigital Solution | Woodmead | Digital Transformation Product and Services | |
| SmartMallSA | Johannesburg | Online marketplace | |
| SMARTPEEPS WELLNESS COACHING FORUM | johanesburg | WEIGHT LOSS | |
| SmartPros Business Solutions | Johannesburg | FTTH, FTTB, HaaS (Hardware sales & rental) | |
| SmartRetail | Pretoria | Smart Trade Point Of Sale Software And Hardware | |
| SMARTSIGNS | Johannesburg | Signage Manufcturer: Design-Manufacture-Install | |
| SME.Tax | Centurion, Gauteng | Accounting; Tax; Payroll, Business Consulting | |
| Smit & Van Wyk | Pretoria | Patents, Trademarks, Copyright | |
| Smith And Daniels | Johannesburg | Portraits, automotive, advertising , commercial | |
| SMSGUYS | Sandton | Bulk SMS Marketing | |
| Snail Attorneys @ LAW | Pretoria | Litigation, Cyberlaw / IT Law, Labour Law, | |
| Snail Attorneys at Law | Pretoria | Cyber Law, conferencing, Labour, Civil, consulting | |
| Snappi Holdings | Pretoria | Manufacture & distribute baby products. | |
| Snatech Printer Cartridges | Pretoria | supplier of Toners | |
| Snippet Video | Randburg | Snippet Video | |
| SNK Consulting Logistics | Isando | LOGISTICS; SUPPLY CHAIN; DISTRIBUTION | |
| SNWS Digital | Brakpan | Web design , Graphic design, logo design, | |
| So Shine Events Management | Pretoria | Conferencing, Travel | |
| Soap Visuals | Photography and Videography | ||
| Soaring Heights Productions | Video Production and Drone Services | ||
| Sobethu Media | Johannesburg | Video and Audio production | |
| Sobg Contracting | Johannesburg | Construction | |
| Social Enterprises Management Accountants | Johannesburg | Small Business Consulting and Accounting | |
| Social Incubator | Fourways | social media marketing | |
| Social Media Marketing Africa | Sandton | Advertising Agency | |
| Social Path | Johannesburg | Social Path | |
| Socks For Africa | Vanderbijlpark | Socks | |
| Softkings IT Solutions | Pretoria | Fibre & ADSL | |
| Softserve Digital Development | Jhb | We design & develop amazing websites and apps | |
| Software Realisations | South Africa | Software Development | |
| Soit Business Solutions | Randburg | Computer Company | |
| Solar Advice | Johannesburg | Online Distribution | |
| Solar Corporation | Pretoria | Solar power, Solar Heating, Solar Geysers | |
| Solar Deals | Benoni | Solar Energy Product Supplier | |
| Solar Heat Exchangers | Randburg | Design, Supply and Install Solar Thermal Hot water | |
| Solar Installers | Pretoria | electricians | |
| Solar Links Energy | Randburg | Solar links | |
| Solar Panel Energy | Vanderbijlpark | Online Distribution | |
| Solid Systems | Johannesburg | Microsoft Specialists | |
| Solidum Recruitment Agency | Pretoria | Recruitment | |
| Solomons Cycles | Pretoria East | Cycling | |
| Solprov | Engineering | ||
| Solutions Group Events | Bryanston | Conference & Event Management, Incentive Travel | |
| Solutionsfinding | Pretoria | Whole Brain Solutions | |
| Somethingraphic | Graphic Design | ||
| SOMS Digital | Sandton | Digital Marketing Services | |
| Sonja Shear Coaching and Consulting | Benoni | Business Coaching | |
| Sonja Shear Coaching and Consulting | Johannesburg | Training and coaching | |
| Sophisticated Office Solutions | Supply Office Furniture, PPE & Corporate Clothing | ||
| Soror Language Services - Arabic Translation | Honeydew | Soror Language Services | |
| Sorted Design + Advertising | Pretoria | Graphic Design, Advertising, Web Design, Branding | |
| SOS Freight | Alrode South | Freight and logistics with competitive pricing. | |
| Soul Clap TV | Sandton | Video Production Company | |
| Soul Connection | North Riding | Alternative Therapies, Healings and Teachings | |
| Soul Reflections Photography | Centurion | Photography | |
| Soulfilter | Roodepoort | Video editing design motion graphics animation VFX | |
| SoulWorx Events | Johannesburg | Content provider | |
| SoulWorx Production Company (SWP) | Johannesburg | Content provider | |
| Sound & Motion Studios | Johannesburg | Recording and Production, Music and Film | |
| Sound Hire Johannesburg | Randburg | Sound and projector hire for conferences | |
| Sound HQ Solutions | Krugersdorp | Technical Suppliers | |
| Sound Proprietors | Johannesburg | Sound Engineering Company | |
| Sound Stylists (Pty) Ltd | Johannesburg | Full Technical Turnkey solutions | |
| Soundmatic sa | Brakpan | Soundmatic sa | |
| Soundworx Entertainment | Randburg | Supply of DJ's for weddings, corporates and events | |
| Sourcing Magic | Sandton | Clothing, gifts, customised, USB | |
| South Africa | Johannesburg | Traditional Healer | |
| South African Canine Breed Registry | BRAKPAN | Registration of All Purebred dogs | |
| South African Community Link | Ekurhuleni | Billboards/Street Poles/Citilites/Building Wrap | |
| South African Film Empowerment | Pretoria | Film Making and Acting | |
| South African Garage Door Association | Roodepoort | Garage Doors and Automation | |
| South Point | Johannesburg | Student Accommodation | |
| Southern Spoor | Fourways | Marketing of hotels and lodges | |
| Southern Transcription and Recording Services | Johannesburg | Transcribing Recordings | |
| Southgate Courier Service | Boksburg | Import and Export Courier Services | |
| Southgate Courier Services | Boksburg | Import and Export Courier Services | |
| Sovtech SA | Johannesburg | Software Developement Company | |
| SovTech Software Development | Randburg | SovTech is a custom software development company i | |
| SovTech South Africa | Randburg | Software Development Company |
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