A new anticancer vaccine study starts at The James

23 Mar 2011

A new early phase clinical trial investigating the safety of an experimental anticancer vaccine designed to prevent a number of types of solid tumours is under way at the Ohio State University Comprehensive Cancer Centre - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC - James).

The experimental vaccine targets two specific regions of the human epidermal growth factor receptor 2 (HER-2), a molecule that occurs in abnormally high levels in up to 30% of breast cancers. Another component of the vaccine targets HER-1 (EGFR) a molecule that is over-expressed in many other solid tumours, including ovarian, renal, colon, lung, and gastro-intestinal cancers, says researcher Pravin Kaumaya, PhD, professor and director of the vaccine research division in the Department of Obstetrics and Gynecology. Kaumaya led the development of the protocol for this NCI funded trial, as well as development of the vaccine.

The goals

The goals of the phase I trial include determining the safety and optimal dose of the HER-2 vaccine; evaluating whether the vaccine shows therapeutic benefit by stimulating the immune system to respond to the patient's tumour; and documenting any clinical responses that may occur. In addition, Kaumaya says, this phase I study includes an innovative efficacy arm that was approved by the Food and Drug Administration, which must okay all clinical trials conducted in the United States.

Study participants must be 18 years of age or older and have a metastatic solid tumour that is considered incurable using standard treatment. Patients with tumours that do not express the HER-2 molecule may also be eligible to participate.

For further information about enrolling in the study, please call the OSUCCC - James at 1-800-293-5066.

The Ohio State University Comprehensive Cancer Centre - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (http://cancer.osu.edu) is one of only 40 Comprehensive Cancer Centres in the United States designated by the National Cancer Institute. Ranked by US News & World Report among the top cancer hospitals in the nation, The James is the 205-bed adult patient-care component of the cancer program at The Ohio State University. The OSUCCC-James is one of only seven funded programs in the country approved by the NCI to conduct both Phase I and Phase II clinical trials.

Source: Ohio State University