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| DC Enterprises | Brackenfell | Plastic injection Moulded products, Promotional | |
| DCI Scanning | Cape Town | Barcoding Scanners & Labels | |
| DCL Creative - Video, Media & Tech | Cape Town | Video as digital strategy in media | |
| De DaBaba Studios | Cape Town | Pro Digital Video Productions | |
| De Smit Eksklusiewe Strukture | Cape Town | De Smit | |
| DEAL Training Consultants | Bellville | Corporate Training & Development | |
| Debt Consolidation | Consumer Relief | Durban | http://consumerrelief.co.za/ | |
| Debt Review SA | Paarl | Debt Review and Counselling | |
| Decobella | Cape Town | Tile importer and national distributor | |
| Decorton Retaining Systems | Paarl | Specialist Retaining Wall Contractors & Civil Work | |
| Deep Thought Media | Cape Town | Digital Marketing Solution - Web Development | |
| Deep Thought Media | Cape Town | Web Design, Google Advertising, SEO, Social Media | |
| Dermatech | Cape Town | Offer training in Hair, Health and Skincare | |
| Deros Recruitment | Cape Town | Contingency recruitment | |
| Derryn Brigg Consulting | Cape Town | Business Planning | |
| Desert Rose Music | Cape Town | Music Production and live performances/workshops | |
| Design by Think | Cape Town | Marketing, design, website development, printing. | |
| Design Connection ZA | Cape Town | eLearning Development | |
| Design From Cape Town | Cape Town | 5 Upper Chamberlain Street, Woodstock, Cape Town | |
| Design Guru | Somerset West | Web Design & Development, Hosting, Email, Domains | |
| Design Kebab | Cape Town | Graphic design, web development, advertising | |
| Designet | Cape Town | Website Design and Development | |
| Designology | Cape Town | Design | |
| Designs for Development | Cape Town | Graphic design | |
| DesignThinkers Group & Academy | Cape Town | Design Thinking, Service Design | |
| DevLabs | Cape Town | Bespoke web and mobile app development | |
| Devmob | Cape Town | Custom build management tools for stock, finance | |
| DI Manage | Stellenbosch | Human Resources and Employee Relations | |
| Di Rosen Productions | Cape Town | Producing and Directing TV All Genres | |
| Dial a Contractor - Cape Town | Cape Town | Building and Construction Contractors | |
| Dial A Contractor - Gauteng | Cape Town | Building Services | |
| Dial-a-Picnic | Cape Town | Picnic Events & Special Occasions | |
| Dialogue PR | Cape Town | Public Relations | |
| DialSA | Cape Town | internet access | |
| Diamond Epoxy Coating | Cape Town | Industrial powder coating | |
| Die Nooitgedacht Pers | Cape Town | Commercial printing | |
| Diep River Plumbers | Cape Town | Diep River Plumbers | |
| Dig It All Marketing | Digital, Social Media, Content & Event Marketing | ||
| DiGiCiG | Cape Town | Retail, wholesale, distribution and ecommerce | |
| Digital Business Academy | Cape Town | Social Media and Digital Marketing training | |
| Digital Diamonds | Cape Town | Online Marketing, Web Development, Digital Design | |
| Digital Forensics | Cape Town | IT Services | |
| Digital Forest Studio | Cape Town | Music Production, Mixing, Radio & TV Sound Design | |
| Digital Lime Green | Cape Town | Website Design and Digital Marketing Agency | |
| Digital marketing agency Cape Town | Nelon | Cape Town | Branding | |
| Digital Presence | Paarl | Digital marketing | |
| Digital Projects | Cape Town | Web Design and Development | |
| Digital Socialite | Cape Town | Online Reputation Managemet Social Media | |
| Digital Xposure Photography | Cape Town | Photographer Cape Town 25 years experience | |
| DigitalBeyond | Stellenbosch | eCommerce & Web | |
| DigitalStartup Agency | Cape Town | Chatbot & Messenger Marketing Expert | |
| Digitech Innovative Solutions | Cape Town | Smart Technology | |
| DigiVision | Cape Town | Broadcast Television Equipment Supplier | |
| Dilingua Language Services | Cape Town | Translation & Interpretation | |
| Dimensional Stunt School | STUNT TRAINING INSTITUTION | ||
| Direction Films | Cape Town | Producing of TV commercials and other content | |
| Discmedia Cape | Cape Town | cd/dvd duplication/printing blu ray printing | |
| Discount Factory Shops | Cape Town | Retail Information Portal | |
| Disko | Cape Town | Animation, 3D | |
| Display Mania International | Cape Town | Snap Frames, Pull-Up Banners, Light Boxes, Gazebos | |
| Distinctive Choice t/a Lie and Tell | Cape Town | Truth Verification | |
| Distribution Management Services | Cape Town | Business Management Consultant | |
| Divine Brand Intervention | Cape Town | Packaging Design, Corporate Indentity, POS design | |
| Divorce Lawyers Cape Town | Cape Town, | Divorce Lawyers Cape Town | |
| DJ's Model Agency | Cape Town | Casting Agency | |
| DLPHOTO | Cape Town | Photography School & Studio | |
| Dlphoto Photo Studios | CAPE TOWN | Photography services | |
| dmg Events | Johannesburg | Exhibitions | |
| DMH Talent Agency | Cape Town | Talent Management/Models/Actors/Singers/Dancers | |
| DNA Cleaning | Cape Town | Selling of natural cleaning products | |
| DNA Community | Cape Town | Business and Growth Hacking | |
| DNA Studios | Cape Town | film, television, corporate videos & animation | |
| Donald J. Trump Golden Check | New York | Golden Trump Check Reviews | |
| Donnelly Tool Hire | Hermanus | Donnelly Tool Hire | |
| Dont Speak Digital | Cape Town | Dont Speak Digital | |
| DonValley Brand Reputation Managers | Cape Town | Corporate/Brand Reputation Management Consultancy | |
| Door 6 Entertainment | Cape Town | Corporate Functions, Live Shows and Entertainment | |
| Doors and Drawers The Custom Wood and Steel Co. | Cape Town | Kitchens, Joinery, Steel and custom furniture | |
| DOT Effect Solutions | Cape Town | IT consulting | |
| DotActiv | Germiston | Category Management Software/Services | |
| Dotjam | Multi-channel strategic consultancy | ||
| Dowd Engravers Pezula signage solutions | Cape Town | industrial manufacturing, lasercutting, printing | |
| Down South Towing | Cape Town | 24 hour mechanical and breakdown service | |
| DPI Concepts | george | Branding | |
| Dr Alek Nikolic | Cape Town | 33 Piers Road Wynberg Cape Town | |
| Dr Andre De Villiers - Orthodontist | Cape Town | Orthodontist | |
| Dr JJ Serfontein | JJS Dentistry Cape Town | Cape Town | Dentistry | |
| Dr Kay U. Brugge | Cape Town | Life Coaching, Mentoring, Life Strategy | |
| Dr Leana van Dyk | Paediatrician | Cape Town | Medical Practice | |
| Dr Natalia Novikova | Cape Town | Gynaecologist | |
| Dr S Ranchod | Cape Town, South Africa | Maxillofacial and Oral Surgery | |
| Dr Sizwe Derrick Mthiyane | Richards Bay | Medical Practice | |
| Dr Sunil Thakersee | Cardiologist Cape Town | Cape Town | Medical Practice | |
| Dr Tanja Beeton Audiologist | Cape Town | Audiology |
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