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| Dr Candice Mnguni | Johannesburg | Healthcare | |
| Dr Gerald B Kaplan | Johannesburg | Dental | |
| Dr JJ Serfontein | JJS Dentistry Cape Town | Cape Town | Dentistry | |
| Dr Katri du Toit | Pretoria | Homeopathic practitioner | |
| Dr Kay U. Brugge | Cape Town | Life Coaching, Mentoring, Life Strategy | |
| Dr Khali Thenga | Johannesburg | Psychotherapy and market research | |
| Dr Leana van Dyk | Paediatrician | Cape Town | Medical Practice | |
| Dr M Khusal | Sandton | Painless dental work | |
| DR Muhammed A Traditional Healer In South Africa | Johannesburg | health | |
| DR Nachlas | drnachlasinfo | ||
| Dr Natalia Novikova | Cape Town | Gynaecologist | |
| Dr Richard Wayman Chiropractor | Randburg | Chiropractor | |
| Dr Ronel Podde Inc. | Pretoria | Dental Surgeon | |
| Dr S Ranchod | Cape Town, South Africa | Maxillofacial and Oral Surgery | |
| Dr Sizwe Derrick Mthiyane | Richards Bay | Medical Practice | |
| Dr Sunil Thakersee | Cardiologist Cape Town | Cape Town | Medical Practice | |
| Dr Tanja Beeton Audiologist | Cape Town | Audiology | |
| Dr. S. Sibisi | Mabopane Medical Centre | Mabopane | Doctor | |
| Dragon Consulting | Johannesburg | Research Capacity, Research Services | |
| Dragon Pharam SA | South African distributors of Dragon Pharma sports | ||
| Dragonfly Direct Marketing SA | Cape Town | Direct Marketing and Print Management Specialists | |
| Drain Ratz Plumbing | Pretoria | Drain Ratz Plumbing | |
| Drainbusters Plumbing | Theodore | Plumbing | |
| Drake Events | Johannesburg | Event Services | Drinks, Decor, Staff | |
| Dramarising | dramarising | ||
| Drawing Board Marketing | Port Elizabeth | Marketing | |
| Drawing From Observation | Johannesburg | visual arts | |
| Dream Photography | Durban | Wedding Photography | |
| Dream Team Auto | Rock Island | Dream Team Auto LLC | |
| Dream Team Catalyst | Johannesburg | Teambuilding, Motivation, Conference Entertainment | |
| DREAM TEAM WORLD | Cape Town | Branded Entertainment specialists, reality tv | |
| Dreamcast | Edenvale | Manufacturing | |
| Dreamchaser Sports and Entertainment | Fourways | Legal Advisory and Sports & Entertainment Agency | |
| Dreamcoatpainting | Umhlanga | Dreamcoat is a multi-disciplined professional. | |
| Dreams | Pringle Bay | Self catering holiday home 100m from beach, CT | |
| Dreams of Fire Productions | Muldersdrif | Entertainment production, placement and management | |
| Dreamsmiths Digital | Cape Town | Software Development | |
| DreamWorld | Johannesburg | Marketing & Advertising | |
| Dredging Sevices | Hermanus | Dredging | |
| Dreymar Industrial | Warehouse Equipment | ||
| Drink Invaders | BAR | ||
| DrinksFeed | Cape Town | Digital Marketing | |
| Drip Data Software | Johannesburg | Custom Software Development | |
| Drive South Africa | Cape Town | Car rental, 4x4 rental, camper rental | |
| Driveshafts Centre | Cape Town | Driveshafts, Propshafts, Suspension, Steering Rack | |
| Driveway Paving Huntington | Huntington | Driveway Paving Huntington | |
| Driving Directions | Driving directions | ||
| Driving Lessons Cape Town | Stellenbosch | Driving Lessons | |
| DrMzi Bridging The Gap | Sandton | Consulting to non-profit/CSI sector | |
| DropaLoad Toilet Hire | Midvaal | Hire and Sales of Portable Toilets, Sheds & Septic | |
| Druff Interactive | Pretoria | Branding and Design | |
| Drum Tribe | Johannesburg | Teambuilding and Events | |
| Drum Tribe - Johannesburg | Johannesburg | Interactive Drumming/Gumboot Dancing/Team Building | |
| Drum Tribe SA | Johannesburg Area, South Africa | Teambuilding - performances | |
| Drutech Media | Digital Marketing Agency | Johannesburg | Digital Marketing | |
| DrWriting | Essay writing | ||
| DryForce | Cape Town | Restoration | |
| Drywall Victoria CNL | Victoria | John Cracknell | |
| DS Productions | Johannesburg | Entertainment | |
| DSA Window Cleaning | Somerset West | Window Cleaning | |
| DSH Group | Johannesburg | Investment | |
| Dslot123 | http://slot88.xyz/ | ||
| DST PRINTING | Centurion | EMBROIDERY | |
| Dstv Pro Technicians | We Do Dstv and Cctv Installations around all Weste | ||
| DTP Mag | Johannesburg | Magazine and general typesetting | |
| Du Plessis Accounting | Heidelberg | For all accounting needs, from petty cash to tax | |
| Dubaivisitvisaonline | dubai | travel | |
| Duck and Craig | Jhb | Full-service advertising and media agency | |
| Ductworth Extraction Cleaning Services | Cape Town | Restaurant Extraction Servicing, Canopy Cleaning | |
| Duke of Print | Johannesburg | Litho & Digital Printing | |
| Duma Lodge | Nelspruit | Luxury affordable accomidation and restaurant | |
| Dumbbell Supplier China - Fitness Equipment | London | Dumbbell Supplier China - Fitness Equipment | |
| DuMore Projects | Johannesburg | Facilities Management, Property maintenance | |
| Dunamis Food and Events | Johannesburg | Catering Events planning | |
| Dunamis Tech | Pretoria | Websites, E-commerce, SEO, Marketing | |
| Duncan Logistics RSA | Johannesburg | Removals. | |
| Dung Beetle Creative Studio | Johannesburg | Presentation Design | |
| Dunia Poker 24 Jam 123 | MARKETING | ||
| Duplex Steel Fasteners | Duplex Steel Fasteners | ||
| Duplicate-IT | Edenvale | Printing and Duplication | |
| Durban Cosmetics and Detergents | Durban | Supplier of Cleaning Materials | |
| Durban Manor Hotel & Conference Centre | Durban | Hotel Accommodation and Conference Centre | |
| Durban Research Studio (DRS) | Durban | focus group venue | |
| Durbanville Painters | Bellville | Painting Contractors | |
| Dust-A-Side | Centurion | Mining Consultant | |
| Dusted Cleaning Services | krugersdrop | 2 Galaway Rd , kenmare, krugersdrop 1739 | |
| Dutch Manor Antique Hotel | Cape Town | Accommodation | |
| Dutchink Digital Advertising House | Durban North | Digital Advertising House | |
| Duvalele Luxury Tours and Travel | Airport transfers and shuttle | ||
| Duzi Tent Hire | Pietermartzburg | Function hire | |
| DVR Civils | Port elizabeth | Construction, Renovations, Decking, Architecture | |
| DVT | Software development, mobile apps, AI/ML | ||
| Dyanna Spa & Waxing Center - Midtown Manhattan | New York | Beauty Salon, Facial spa, Hair removal service | |
| Dyeandprints (Sole Proprietor) | Uniondale | Online learning for textile enthusiasts | |
| Dynamic Brands Manufacturing | East London | Fusion,Rascals,Mr Orange,Elvin,Slimsy,Delicious |
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