| Deepsmart Consulting | Pretoria | Marketing | |
| Deevine Media | Johannesburg | Media Production | |
| Deez Hippie Valley | Johannesburg | Hand tie-dyed clothing (Hippie style) for any occ. | |
| Defining Moment Fitness | | Gym | |
| DefinIT | | Content Creation | |
| Deja Vu Varsity | Polokwane (Pietersburg) | Independent Higher Education Institution | |
| Dekor Blinds West Rand | Roodepoort | Wooden Blinds/Roller Blinds/Curtains | |
| Dekorhuys | Pretoria | Blinds, awnings, shutters, curtains and wallpaper | |
| Del Toro PPE | Pretoria | Covid 19 Products, Masks, Gloves, Sanitsers | |
| Delgado Consultants | Centurion | Healthcare, consulting, strategies, education | |
| Delicious Designs - Graphic Design Boutique | Westdene | Graphic Design | |
| Delivery Solutionz | | Delivery Solutions. Courier services. Transportati | |
| Delphis Eco | Robertville | Eco-Friendly Chemical Manufacturing | |
| Delta Force Security Services | Nelspruit | Direct Marketing | |
| Delta Steam Systems | Cape Town | Engineering | |
| Demal Solutions | Johannesburg | logo mats | |
| Dende Troop | | promo creation | |
| Dental Brands Australia | | Dental Brands Australia | |
| Deo Volente | Johannesburg | Marketing Printing Design | |
| Deon Binneman | Johannesburg | Reputation Management Consulting & Training | |
| Deon’s Auto Panels | Krugersdorp | Deon’s Auto Panels | |
| Derma Correct Remove Dark Circles | New York City | Derma Correct | |
| DermalMD | Plantation | DermalMD | |
| Dermaniche | | beauty product marketing | |
| Dermatech | Cape Town | Offer training in Hair, Health and Skincare | |
| Deros Recruitment | Cape Town | Contingency recruitment | |
| Derryn Brigg Consulting | Cape Town | Business Planning | |
| DERWALT PTY LTD | Johannesburg | Activations|Entertainment|Events|Communication | |
| Desert Jewels Belly Dance Company | Norwood | Belly dance classes and performances | |
| Desert Rose Communications Management | Durban | Management of internal and external communications | |
| Desert Rose Music | Cape Town | Music Production and live performances/workshops | |
| Desi Matka | | Satta Matka | |
| Design by Think | Cape Town | Marketing, design, website development, printing. | |
| Design Connection ZA | Cape Town | eLearning Development | |
| Design Divas | Pretoria | Graphic design | |
| Design From Cape Town | Cape Town | 5 Upper Chamberlain Street, Woodstock, Cape Town | |
| Design Guru | Somerset West | Web Design & Development, Hosting, Email, Domains | |
| Design Kebab | Cape Town | Graphic design, web development, advertising | |
| Design Zeen Marketing Agency | | SEO & Website Design & Development | |
| Design@Bay. | Port Elizabeth | Strategic Branding and Communication Design | |
| Designer Concrete Flooring | Johannesburg | Transform Your Old Concrete Flooring, Brick Paving | |
| Designer Doors | Randburg | Aluminium Windows & Doors | |
| DESIGNERAMA | Johannesburg | UX, UI & Interaction Design | |
| Designet | Cape Town | Website Design and Development | |
| designlogik | Stellenbosch | Graphic Design | |
| DesignMedia | Centurion | Graphic & Web Design | |
| Designology | Cape Town | Design | |
| Designs for Development | Cape Town | Graphic design | |
| DesignTech Training Academy | Midrand | Microsoft Training, Technical, Business Skills | |
| DesignThinkers Group & Academy | Cape Town | Design Thinking, Service Design | |
| Designwave | Pretoria | Graphic Design - Print and Web Design | |
| Desire Body Sculpting and Wellness Spa | Lilburn | laser lipo, laser liposuction, laser lipo body | |
| DeskLink Media | Randburg | Publishing | |
| Deskotia Consulting | Pretoria CBD | Shelf companies are available: one day service | |
| Deslow Creations | Kuils River | Web cevelopment and creation | |
| DeStress & Relax Mobile Massage | Mokopane | We offer therapeutic massages at home/work | |
| DeStress & Relax Mobile Massage. | Mokopane (Potgietersrus) | Massage | |
| Deta IT Business | Johannesburg | Web Design & Development | |
| Devci Innovations | | Digital Marketing | |
| Developer | | N/A | |
| Developing Restaurants | | Developing Restaurants | |
| DevLabs | Cape Town | Bespoke web and mobile app development | |
| Devmob | Cape Town | Custom build management tools for stock, finance | |
| Devolden Group | Benoni | Training of Employees | |
| DevOps Business | Johannesburg | Website Design Development/E-Commerce WordPress | |
| Dextara Digital | | Salesforce Consulting and Implementation Services | |
| Deyima Engineers | Port Elizabeth | Hand Sanitizer 70% Alcohol | |
| Dezign81 Agency | | Graphic Design, Web Development | |
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| DFS Trading | Johannesburg | New and Second Hand clothing wholesalers | |
| Dfsadfdf | | Direct marketing | |
| dGit Labs | Mogale City | Software Development. | |
| Dhanesh Fundraising and Project Consulting | Soekmekaar | Fundraising and project consulting | |
| Dhewas Handyman Services | Benoni | Property Maintenance Waterproofing and Painting | |
| Di and Flo Trading and Projects | Bloemfontein | Catering Services | |
| DI Manage | Stellenbosch | Human Resources and Employee Relations | |
| Di O Rara Personnel | Johannesburg | Di O Rara Personnel is a recruitment agency. | |
| Di Rosen Productions | Cape Town | Producing and Directing TV All Genres | |
| Diab Computers | Boksburg | Sales, web hosting, support | |
| Dial a Contractor - Cape Town | Cape Town | Building and Construction Contractors | |
| Dial a Contractor - Durban | Phoenix | Building and Construction Contractors | |
| Dial A Contractor - Gauteng | Johannesburg | Building Services | |
| Dial-a-Picnic | Cape Town | Picnic Events & Special Occasions | |
| Dialogue PR | Cape Town | Public Relations | |
| DialSA | Cape Town | internet access | |
| Diamond Coaching and SME Coach | Johannesburg | Business improvement coaching for SMEs | |
| Diamond Epoxy Coating | Cape Town | Industrial powder coating | |
| Diamonds and Jewels | Johannesburg | Diamonds and Jewellery sales | |
| Diaries For Sale | Johannesburg | Diaries | |
| Diary Printing | johannesburg | DIARY SUPPLIERS | |
| Dici Leadership Institute | | Coaching, Consulting & Entrepreneurship | |
