Genes and obesity: Fast food is not only culprit in expanding waistlines - DNA is also to blame

(Image: UCLA)

The study is the first of its kind to detail metabolic responses to a high-fat, high-sugar diet in a large and diverse mouse population under defined environmental conditions, modelling closely what is likely to occur in human populations. The researchers found that the amount of food consumed contributed only modestly to the degree of obesity.

The findings were published on 8 January in the online edition of the journal Cell Metabolism and appeared on 9 January in the print version.

'Our research demonstrates that body-fat responses to high-fat, high-sugar diets have a very strong genetic component, and we have identified several genetic factors potentially regulating these responses,' said first author Dr. Brian Parks, a postdoctoral researcher at the David Geffen School of Medicine at UCLA. 'We found that obesity has similar genetic signatures in mice and humans, indicating the mice are a highly relevant model system to study obesity. Overall, our work has broad implications concerning the genetic nature of obesity and weight gain.' Read the rest of the article.