Kidneys from young donors considered safe and effective for transplantation
In most transplant centres, the kidneys of very young deceased donors are transplanted together into one patient. According to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN), a single kidney from a very young deceased donor maintains the health of an adult with kidney failure.
Determining the minimum donor age or body weight for splitting kidneys for transplant is controversial. Transplanting both paediatric kidneys into an adult theoretically provides better kidney function, and surgeons do not usually divide kidneys when the donor is under five years of age. However, giving each of two patients in need one organ from the same donor could increase kidney transplants: in the United States approximately 80 000 individuals are waiting for kidney transplants, and 4000 die each year before receiving transplants. Rubin Zhang, MD (Tulane Abdominal Transplant Institute), and his colleagues compared the long-term health of adult patients after they were transplanted with either single paediatric kidneys from donors less than five years of age or single kidneys from donors more than five but less than 10 years of age.
The researchers' study included all 79 adults who were transplanted at the Tulane Abdominal Transplant Institute with single paediatric kidneys from deceased donors aged 10 years or less between January 1996 and June 2007. Physicians transplanted a single paediatric kidney if it was healthy enough for splitting and the recipient consented. Half of the adults received single paediatric kidneys from donors less than five years of age. The other half received single kidneys from donors aged five to 10 years.
Similar rates of kidney rejection
While more patients in the group that received a kidney from the youngest donors (73%) needed ureteral stents (tubes inserted to help drain urine from the kidney) than patients in the other group (38%), complications that required additional surgery were similar in the two groups. Patients in the two groups experienced similar rates of kidney rejection and delayed kidney function. In both groups, kidney function improved dramatically in the first year after transplant, and it continued to improve into the third year. Furthermore, patients in the two groups lived a similar length of time. The youngest donor in the study was a nine-month old female; both of her donated kidneys remain healthy more than six years post-transplantation into two different recipients.
While other studies have reported more complications when single kidneys from very young donors are transplanted into adults, this study found that the practice is safe and effective. "Single paediatric kidney transplants from donors less than five years can be utilized with acceptable complications and good long-term outcomes" the authors concluded.
The authors report no financial disclosures. Study co-authors include Anil Paramesh, MD, Sandy Florman, MD, C. Lillian Yau, PhD, Saravanan Balamuthusamy, MD, N. Kevin Krane, MD, and Douglas Slakey, MD (Tuland Abdominal Transplant Institute).
