Human gut 'selects and nurtures' beneficial microbes
Animals, including humans, actively select the gut microbes that are the best partners and nurture them with nutritious secretions, a new Oxford University study suggests.
The Oxford team created an evolutionary computer model of interactions between gut microbes and the lining (the host epithelial cell layer) of the animal gut. The model shows that slow-growing beneficial microbes are rapidly lost and need to be helped by host secretions, such as specific nutrients, that favour the beneficial microbes over harmful microbes.
The work also shows that the cost of such selectivity is low: the host only needs to use very small amounts of secretions to keep beneficial microbes that would otherwise have been lost.
A report of the research appears in the journal PLOS Biology.
"The cells of our bodies are greatly outnumbered by the microbes that live on us and, in particular, in our gut," said Professor Kevin Foster of Oxford University's Department of Zoology, an author of the report. 'We know that many gut microbes are highly beneficial, protecting us from pathogens and helping us with digestion, but quite how such a beneficial mutual relationship evolved, and how it is maintained, has been something of a mystery.
"This research highlights the importance of growth-promoting substances in our ability to control the microbes that live inside us. It shows that nutrients are more powerful when released by the host epithelial cell layer rather than coming from the food in the gut, and suggests that controlling our microbes is easier than was previously thought."
Jonas Schulter of Oxford University's Department of Zoology, first author of the report, said: "The inside of our gut is rather like a war zone, with all kinds of microbes battling it out for survival and fighting over territory. Our study shows that hosts only have to secrete a small quantity of substances that slightly favour beneficial microbes to tip the balance of this conflict: it means that favoured microbial species that would otherwise be lost don't just survive on the epithelial surface but expand, pushing any other strains out."
The team's simulations show that cells affected by host epithelial selection are least likely to be lost and persist longest causing "selectivity amplification": a way that relatively tiny changes instituted by the host - in this case very small amounts of secretions of certain compounds - can be amplified to produce a large-scale effect.
Selectivity amplification may occur in a range of other interactions between hosts and microbes, including the microbes that grow on the surface of corals and the roots of plants.
A report of the research, entitled 'The Evolution of Mutualism in Gut Microbiota via Host Epithelial Selection' by Jonas Schulter and Kevin Foster, is published in PLOS Biology on 20 November 2012.
Source: Oxford University