In the accompanying movie, defective NPCs are sequestered into a specialized compartment (colored red) that is retained in the mother cell, while each daughter inherits functional NPCs. "It is important to understand how these gatekeepers, which are fundamental to cellular function, are built and maintained," Lusk said.
As befitting life's blueprint, DNA is surrounded by an elaborate security system that assures crucial information is imparted without error.
The security is provided by a double membrane perforated by protein channels that block unwanted material from entering the nucleus and promote entry of key messengers. The breakdown of these channels, called nuclear pore complexes (NPCs), is associated with some forms of cancer and with aging.
Source: Yale University
